Aims: We assessed the efficacy (subjective pain intensity and disability) and feasibility (attrition, adherence and safety) of a 12-week running intervention in individuals with chronic low back pain compared to waitlist control.
Methods: Participants (n=40, mean [SD] age: 33 [6] years, female: 50%) with non-specific chronic low back pain were randomised to the intervention or waitlist control group. Following initial assessment, the intervention group completed a 12-week progressive run-walk interval training program comprising three 30-minute digitally-delivered community-based exercise sessions per week under the supervision of an exercise physiologist. At baseline and 12 weeks, low back pain intensity (100-point visual analogue scale) and disability (Oswestry Disability Index; 0-100 points) were assessed. Feasibility outcomes included attrition at follow-up, training session adherence and the number and seriousness of adverse events. Linear mixed models with an intention-to-treat approach were used to evaluate between-group differences.
Results: There was no attrition, mean [SD] training adherence was 70 [20%] (2.1 of 3 sessions per week) and running distance increased from 2.9 [1.3] to 5.6 [5.3] km per week from baseline to 12 weeks. Nine adverse events deemed likely study-related were reported in the intervention group, of which all were non-serious; seven were related to lower limb injury/pain (knee or ankle), one to pre-existing cardiac syncope and only one to an increase of low back pain. When compared to control, running decreased both pain intensity (mean between-group difference [95%CI]: -15.30 [-25.33, -5.27] points, P=0.003) and disability (-5.20 [-10.12, -0.24] points, P=0.038) at 12 weeks.
Conclusions: A 12-week run-walk intervention appears acceptable, safe, and effective in individuals with non-specific chronic low back pain, although the between-group differences did not reach minimal clinically meaningful cut-off scores. Clinicians should monitor for lower limb pain or injury and consider cardiac risk factors when prescribing a run-walk program to individuals with low back pain, but our findings indicate interval running is feasible in this population.