Clinical guidelines recommend non-pharmacological and non-surgical interventions for managing low back pain (LBP). We aimed to summarise the evidence from Cochrane reviews on the efficacy and safety of non-pharmacological and non-surgical interventions for adults with non-specific LBP. We searched randomised controlled trials in the Cochrane Database (up to 15 April 2023). We assessed the quality of the reviews and the certainty of the evidence (AMSTAR-2/GRADE). We included 31 Cochrane reviews of 644 trials that randomised 97,183 adults. There is high confidence in the findings of 19 reviews. The effects were classified into small (less than 10 points on a 0-100 scale or 0.2-0.5 SMD), medium: (>10-20 points on a 0-100 scale or >0.5-0.8 SMD), large effect (≥20 points on a 0-100 scale or ≥0.8 SMD). The best available evidence had moderate certainty. Acute/subacute LBP: Compared to placebo, there is no difference in function in the short term for spinal manipulation. Chronic LBP: Acupuncture: Compared to sham, it provides a small improvement in function in the short term. Compared to no treatment, it provides a medium reduction in pain intensity in the short term and a small improvement in function in the short term. Compared to usual care, it provides a small improvement in function in the short term. Exercise: Compared to no treatment/usual care, it provides a small to medium reduction in pain intensity in the short term and a small improvement in function in the short term.Manual therapies: Compared to sham traction, there is no difference in pain intensity in the short term for traction. Multidisciplinary: Compared to usual care, it provides a medium reduction in pain intensity in the short term and a small improvement in function in the short term. Psychological: Compared to usual care, it reduces pain intensity in the short term, but there is no evidence of it on function in the short term. There is only low certainty evidence that non-pharmacological interventions may not be associated with serious adverse events. In the absence of high-certainty evidence, providers should prioritise 'effective/low risks' interventions with moderate certainty evidence for people with low back pain.